Endocrine Abstracts

Calcitonin and corticotropin-releasing hormone (CRH) are members of a family of neuropeptides that exert effects by activating secretin-type G-protein coupled receptors. Calcitonin lowers blood calcium levels and acts to protect against calcium loss from the skeleton during periods of calcium mobilisation. CRH is a key player in the stress response mediated by the hypothalamic-pituitary-adrenal axis. Analysis of the phylogenetic distribution of calcitonin-type and CRH-type pep...